Department of Bioorganic mechanisms

Head - Andriy I. Vovk,
Dr. Sc., Corresponding Member of NASU, Prof.

The main directions of scientific researches in the department are investigations of mechanisms of bioorganic reactions and bioactivities of natural and synthetic compounds, and also an establishment of correlations between the structure and properties of designed compounds in model chemical and biochemical systems. Researches which are carried out recently are devoted to study of transformations of some vitamins, coenzymes and their structural analogues, research of properties of possible antioxidants, research of new spin probes in model systems, construction and studying of synthetic enzyme inhibitors and computational modellings of bioactivity. Several therapeutically important enzymes are used as possible targets in vitro including acid phosphatases, alkaline phosphatases, protein tyrosine phosphatases, nucleotide pyrophosphatase/phosphodiesterases, glutathione S-transferases, lipoxygenases and xanthine oxidase. Some researches are carried out in scientific cooperation with other scientific groups at the Institute and with laboratories from other Institutes of NAS of Ukraine. We are ready also for new collaboration.

Researches themes

1. "Search and model investigations of potentially bioactive compounds" (2010-2014).
2. "Development of priority trends of synthesis of potential low-molecular bioregulators and research of their properties in model systems" (2007-2011).
3. "Macrocyclic bioregulators. Chemical design and mechanisms of influence" (2007-2009).

Selected publications

1. Vovk, A.I.; Kononets, L.A.; Tanchuk, V.Yu.; Cherenok, S.O.; Drapailo, A.B.; Kalchenko, V.I.; Kukhar, V.P. Inhibition of Yersinia protein tyrosine phosphatase by phosphonate derivatives of calixarenes. Bioorg. Med. Chem. Lett. 2010, 20, 483-487.
2. Vovk, A.I.; Kononets, L.A.; Tanchuk, V.Yu.; Drapailo, A.B.; Kalchenko, V.I.; Kukhar, V.P. Thiacalix[4]arene as Molecular Platform for Design of Alkaline Phosphatase Inhibitors. J. Incl. Phenom. Macrocycl. Chem. 2010, 66, 271-277.
3. Vovk, A. I.; Shivanyuk, A.M.; Bugas, R.V.; Muzychka, O.V.; Melnyk, A.K. Antioxidant and antiradical activities of resorcinarene tetranitroxides. Bioorg. Med. Chem. Lett. 2009, 19, 1314-1317.
4. Vovk, A. I.; Mischenko, I. M.; Tanchuk, V.Yu.; Kachkovskii, G. A.; Sheiko, S.Yu.; Kolodyazhnyi, O.I.; Kukhar, V.P. Stereoselectivity of binding of (N-benzylamino)benzylphosphonic acids to prostatic acid phosphatase. Bioorg. Med. Chem. Lett. 2008, 18, 4620-4623.
5. Vovk, A. I.; Chuiko, A. L.; Kononets, L.A.; Tanchuk, V.Yu.; Muravyova, I.V.; Lozynsky, M.J.; Kukhar, V.P. Inhibition of alkaline phosphatase by thioureido derivatives of methylenebisphosphonic acid. Russ. J. Bioorg. Chem. 2008, 34, 60-66.
6. Vovk, A.; Kalchenko, V.; Tanchuk, V.; Muzychka, O.; Muravyova, I.; Shivanyuk, A.; Cherenok, S.; Kukhar, V. Сalixarene methylenebisphosphonic acids: alkaline phosphatase inhibition and docking studies. Phosphorus, Sulfur, and Silicon and the Related Elements 2008, 183, 625-626.
7. Музичка О.В., Танчук В.Ю., Вовк А.І., Муравйова І.В., Черенок С.О., Кальченко В.І., Кухар В.П. Калікс[4]аренметиленбісфосфонові кислоти: особливості інгібування лужних фосфатаз. Укр. біохім. журн. 2007, 79, 26-33.
8. Garazd, M.M.; Muzychka, O.V.; Vovk, A.I.; Nagorichna, I.V.; Ogorodniichuk, A.S. Modified coumarins. 27. Synthesis and antioxidant activity of 3-substituted 5,7-dihydroxy-4-methylcoumarins. Chem. Nat. Comp. 2007, 43, 19-23.
9. Kochubey, S. M.; Vovk, A. I.; Bondarenko, O. Yu.; Shevchenko, V. V.; Bugas, R. V.; Melnyk, A. K.; Tanchuk, V. Yu. Heterogeneity of thylakoid membranes studied by EPR spin probe. Biochemistry (Moscow) 2007, 72, 558-564.
10. Cherenok, S.; Vovk, A.; Muravyova, I.; Shivanyuk, A.; Kukhar, V.; Lipkowski, J.; Kalchenko V. Calix[4]arene ?-aminophosphonic acids: asymmetric synthesis and enantioselective inhibition of an alkaline phosphatase. Org. Lett. 2006, 8, 549-552.
11. Вовк А.И., Мищенко И.Н. Харченко О.В. Бугас Р.В. БабийЛ.В. Харитоненко А.И. Самусь Н. В. Мельник А.К. Влияние липофильных тиазолиевых солей на фотофосфорилирование в хлоропластах гороха. Физиол. биохим. культ. растений 2005, 37, 109-116.
12. Vovk, A.I.; Kharhenko, O.V.; Kharitonenko, A.I.; Kukhar, V.P., Babiy, L.V.; Kazachkov, M.G.; Melnyk, A.K.; Khichevsky, О.M. Hydrophobic nitroxyl radicals inhibit linoleyl alcohol oxidation by 5-lipoxygenase. Russ. J. Bioorg. Chem. 2004, 30, 391-395.
13. Vovk, A.I.; Kalchenko, V.I.; Cherenok, S.A.; Kukhar, V.P.; Muzychka, O.V.; Lozynsky, M.O. Calix[4]arene methylenebisphosphonic acids as calf intestine alkaline phosphatase inhibitors. Org. Biomol. Chem. 2004, 2, 3162-3166.
14. Патент № 45551 (Україна, Бюл. № 21, 10.11.2009); Патент № 48049 (Україна, Бюл. № 5, 10.03.2010); Патент № 48050 (Україна, Бюл. № 5, 10.03.2010), Патент № 45943 (Україна, 25.11.2009, Бюл. № 22); Патент № 45941 (Україна, 25.11.2009, Бюл. № 22); Патент № 45942 (Україна, 25.11.2009, Бюл. № 22).