Department for Chemistry of Bioactive Nitrogen-Containing Heterocyclic Compounds at the Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine.

Brovarets Vladimir Sergeevich, Doctor of Chemical Sciences, Professor.

Address and other contact information:
1, Murmanskaya Str., Kiev, 02660, Ukraine.
Tel.: +38 (044) 2967154
Fax.: +38 (044) 5732561
e-mail: brovarets@bpci.kiev.ua

A General Direction of Scientific Investigations:
The elaboration of synthetic approaches to new functionalized derivatives of
azoles and azines on the basis of original reagents with N-, P-, S-containing groups.in the last 20 years more than founded on the basis of available amidoalkylating substances 100 original reagents have been introduces into practice of fine organic synthesis. They proved to be very suitable for preparation of new derivatives of various nitrogen heterocycles, among which the substances with high insecticidal, bactericidal and fungicidal activity as well as analgetic, neurotropic and antitumor preparates were found.
It should be mentioned first of all the use of enamides for preparations of 4- and 5-functionalized oxazoles.
It was shown the importance of the new vinylphosphonium reagents as synthetic tools in chemistry of five- and six-membered nitrogen heterocycles. It is quite evident that a variety of cyclization products prepared on the basis of these reagents, may be widely used for studying transmission of electron effects in heterocyclic systems, region- and stereochemical peculiarities of some processes with participation of the reagents as well as for elucidation of a relationship between structure and physiological activity of many new types of heterocyclic compounds.
It is worth mentioning that on original plant grows regulator “Metiur” – one from a functionalized pyrimidine base – was developed in our Department. The study of close analogues of “Metiur” seems to be promising and can be conducted together with a special biological laboratory.

Proposals:
a) We propose to make a contract with a Company or Institute of Biological or Medicinal trend for testing several hundreds of new heterocyclic compounds per year with structure reliable established.
b) The Department can execute any specific project proposed by anyone Company or Institute that it will be concerned with heterocyclic compounds.
c) It is assumed that the total numbers of participants involved in this project will be more than 15 highly skilled researchers capable of solving complex problems of bioorganic chemistry.
d) The realization of this project will be ensured not only by scientific ideas but also by modern technical facility (reliable elemental analisis, high performance liquid chromatography, IR, UV, high-resolution NMR-spectroscopy, X-ray diffraction analysis). In addition, we have at our disposal the best scientific library in Ukraine.