Department for Chemistry of Bioactive Nitrogen-Containing Heterocyclic Compounds at the Institute of Bioorganic Chemistry and Petrochemistry, NAS of Ukraine.

Drach Boris Sergiyovich, Doctor of Chemical Sciences, Professor, a known Ukrainian researcher in the field of phosphorus reagents, heterocyclic compounds and bioorganic chemistry.

From 1986 to the present day Prof. Drach is in charge of the Department for chemistry of Bioactive Nitrogen-Containing Heterocyclic Compounds. He is deeply involved in researches on chemistry of new nitrogen-containing reagents for preparing of bioactive compounds.
He and his disciples managed to find some new reactions and rearrangements and so developed general approaches to derivatives of five- and six-member nitrogen heterocycles. Under his guidance, 20 Candidates and 3 Doctors of Sciences were trained.
Prof. Drach has published more than 250 scientific reports, several reviews and a monograph.

Some from significant publications:
1. B.S.Drach et al. Syntheses of Nitrogen-containing Compounds on the Basis of Amidoalkylating Agents (Monograph) [in Russian].– Kiev: Naukova Dumka.– 1992.
2. B.S.Drach et al. Syntheses of Derivatives of Nitrogen-containing Heterocycles on the Basis of Acylamino-substituted vinyl-phosphonium salts. (Report). Zhurn. Obshch. Khimii.–2002.–Vol.72, N11–P.1764-1790.
3. B.S.Drach et al. New Advances in the Chemistry of functionalized Oxazoles. (Report) in Oxygen- and Sulfur-Containing Hetrocycles, KartsevV.G., Ed., Moscow: IBS Press, 2003, Vol.1, P 58-72.

Address and other contact information:
1, Murmanskaya Str., Kiev, 02660, Ukraine.
Tel.: 8(044) 554715
Fax.: 8(044)5732561
e-mail: drach@bpci.kiev.ua

A General Direction of Scientific Investigations:
The elaboration of synthetic approaches to new functionalized derivatives of
azoles and azines on the basis of original reagents with N-, P-, S-containing groups.in the last 20 years more than founded on the basis of available amidoalkylating substances 100 original reagents have been introduces into practice of fine organic synthesis. They proved to be very suitable for preparation of new derivatives of various nitrogen heterocycles, among which the substances with high insecticidal, bactericidal and fungicidal activity as well as analgetic, neurotropic and antitumor preparates were found.
It should be mentioned first of all the use of enamides for preparations of 4- and 5-functionalized oxazoles.
It was shown the importance of the new vinylphosphonium reagents as synthetic tools in chemistry of five- and six-membered nitrogen heterocycles. It is quite evident that a variety of cyclization products prepared on the basis of these reagents, may be widely used for studying transmission of electron effects in heterocyclic systems, region- and stereochemical peculiarities of some processes with participation of the reagents as well as for elucidation of a relationship between structure and physiological activity of many new types of heterocyclic compounds.
It is worth mentioning that on original plant grows regulator “Metiur” – one from a functionalized pyrimidine base – was developed in our Department. The study of close analogues of “Metiur” seems to be promising and can be conducted together with a special biological laboratory.

Proposals:
a) We propose to make a contract with a Company or Institute of Biological or Medicinal trend for testing several hundreds of new heterocyclic compounds per year with structure reliable established.
b) The Department can execute any specific project proposed by anyone Company or Institute that it will be concerned with heterocyclic compounds.
c) It is assumed that the total numbers of participants involved in this project will be more than 15 highly skilled researchers capable of solving complex problems of bioorganic chemistry.
d) The realization of this project will be ensured not only by scientific ideas but also by modern technical facility (reliable elemental analisis, high performance liquid chromatography, IR, UV, high-resolution NMR-spectroscopy, X-ray diffraction analysis). In addition, we have at our disposal the best scientific library in Ukraine.